New role of Hedgehog signaling in colitis

November 4, 2016

Our study found that inhibition of Hedgehog pathway intensifies colon inflammation in mice. Inflammatory bowel disease (IBD) is a debilitating disorder with limited treatment options. Genetic augmentation of Hedgehog response and systemic small-molecule Hedgehog pathway activation potently ameliorate colitis and restrain initiation and progression of colitis-induced adenocarcinoma. We thus, in this study, identify stromal cells as cellular coordinators of colon inflammation and suggest their pharmacologic manipulation as a potential means to treat colitis. 



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Eunjee Kim received the Best Poster Presentation Award at the 2020 KSMCB Conference

January 21, 2020

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Shin Lab | Department of Life Sciences | Pohang University of Science and Technology