New role of Hedgehog signaling in colitis

November 4, 2016

Our study found that inhibition of Hedgehog pathway intensifies colon inflammation in mice. Inflammatory bowel disease (IBD) is a debilitating disorder with limited treatment options. Genetic augmentation of Hedgehog response and systemic small-molecule Hedgehog pathway activation potently ameliorate colitis and restrain initiation and progression of colitis-induced adenocarcinoma. We thus, in this study, identify stromal cells as cellular coordinators of colon inflammation and suggest their pharmacologic manipulation as a potential means to treat colitis. 

 

 

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Speeding up Sonic Hedgehog slows cancer down

May 28, 2019

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Shin Lab | Department of Life Sciences | Pohang University of Science and Technology