May 28, 2019

In order to grow, cancer cells shut down or over-activate genes that normally maintain a cell’s health. The Sonic Hedgehog gene – named after a Japanese cartoon character – is associated with the cancer of several tissues, including the bladder. In 2014, our team found that losing the Sonic Hedgehog gene (Shh) is necessary for bladder cancers to become aggressive: Shh signals prompt healthy cells near the tumor to inhibit the cancer cell growth, w...

April 18, 2019

Congratulations, Seoyoung! 

Seoyoung Choi, the first year graduate student, received the KEF Award from Kwangjeong Educational Foundation. This scholarship is awarded to the outstanding graduate students who have great potential to excel their fields. Seoyoung plans to use this scholarship to pursue her research on the development of better organoid model platform to study various neurological diseases including schizophrenia. 

September 14, 2018

Congratulations, Eunjee! 

Eunjee Kim received the Best Poster Award at the 2018 Korean Society for Stem Cell Research conference held in August. Eunjee is the first year Ph.D student and her research focuses on the stem cell regulation in various epithelial tissues including bladder and brain.

August 1, 2018

New postdoctoral fellow joined the Shin laboratory this summer! Dr. Jeongwoo Kwon received his Ph.D. at Chungbuk National University, and was recently awarded a Research Fellowship from National Research Foundation of Korea. His research focuses on brain organoids which will be utilized for better understanding of neurological diseases such as schizophrenia and autisms.

October 1, 2017

Sung Eun Kim received the Best Poster Presentation Award at the 2017 International Conference of the Korean Society for Molecular and Cellular Biology held in September. Sung Eun is the first year Ph.D student. Her research focuses on the epigenetic regulation of Hedgehog signaling and its effect on the development of aggressive subtype of bladder cancer called basal urothelial carcinoma which is associated with poor patient survival....

March 13, 2017

In our study, published Mar 9 in Science, we found the novel role of Gli2, the major Hedgehog pathway transcription effectors, on the regulation of a niche signaling program for mammary epithelial stem cells. The mammary gland niche support its associated stem cells while also responding to systemic hormonal regulation that triggers pubertal changes. We found that Gli2 acts within mouse mammary stromal cells to direct a hormone-responsive niche si...

February 20, 2017

Three new grad students joined the Shin laboratory this spring. Yubin Kim, Sangcheol Lee, and Eunjeong Lee joined the laboratory to pursue their Ph.D. in stem cell / cancer research. We are excited to have them in lab, and WELCOME!!!

November 4, 2016

Our study found that inhibition of Hedgehog pathway intensifies colon inflammation in mice. Inflammatory bowel disease (IBD) is a debilitating disorder with limited treatment options. Genetic augmentation of Hedgehog response and systemic small-molecule Hedgehog pathway activation potently ameliorate colitis and restrain initiation and progression of colitis-induced adenocarcinoma. We thus, in this study, identify stromal cells as cellular coordin...

March 1, 2016

We have recently relocated our lab to new University in South Korea. We are now located on the second floor of Life Science Building in the Department of Life Sciences at Pohang University of Science and Technology (POSTECH). We joined the team of many great scientists who work on various diseases and biology. POSTECH is well known as the University with superb scientific environment, and we are very excited to become a member of the POSTECH....

November 2, 2014

In our study, published Nov 02 in Nature Cell Biology (Lim, Shin, Beachy NCB 2014), we found that Hh response in regenerating prostate is present in the stromal cells that enwrap prostate tubules, but is conspicuously absent from stromal cells at the sites of nascent tubule buds. These stromal cells lacking Hh response express higher levels of ​Hgf than Hh-responsive stromal cells, an effect probably mediated by Hh induction of ​miR-26a and ​miR-2...

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Shin Lab | Department of Life Sciences | Pohang University of Science and Technology