Single rosette-based generation of uniform cortical assembloids recapitulating cellular interactions between neurons and glial cells, published in Nature Communications

We are please to announce that our latest research has been published in Nature Communications

In this study, we introduce a single rosette-based, module-driven strategy to generate highly uniform and mature cortical assembloids, addressing a major limitation of conventional brain organoid systems- structural and cellular heterogeneity.

By sequentially reconstituting neuronal and glial modules, our cortical assembloids robustly recapitulate key features of the human cerebral cortex, including six-layered cortical organization, functional connectivity, and dynamic neuron-glia interactions.

This platform provides a reproducible and physiologically relevant 3D human brain-like model, offering a powerful preclinical tool for studying brain development and neurological disorders.

Congratulations to Eunjee and Yunhee for the beautiful work!

Title: Single rosette-based generation of uniform cortical assembloids recapitulating cellular interactions between neurons and glial cells

🔗 https://rdcu.be/eV1sM