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Stem Cell Biology & Human Diseases
Our laboratory currently focuses on three major areas: 1) Stem cell interaction with its microenvironment during tissue regeneration and cancer, with a particular emphasis on the Hedgehog signaling pathway, 2) Development of 3-dimensional in vitro miniature organ systems for precise therapeutic intervention of various human diseases with genetic variability including cancers, and 3) Novel strategy for regenerative medicine with a focus on in vivo tissue reprogramming and genome engineering. To this end, we uses various in vitro/in vivo approaches including mouse genetics and stem cell organoid cutture.
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